Highlighting the Role of Universally Available and Innate Immune Cell Counts in Acute Ischemic Stroke: A Scoping Review

Stroke is one of the leading causes adult disability and second cause death worldwide. The immune system actively participates in pathobiological process acute ischemic stroke (AIS), during index event repair process. Research on neurovascular inflammation has created a renewed interest use easily available biomarkers reflective innate adaptive immunological changes with potential diagnostic, prognostic, therapeutic implications particularly AIS. current scoping review aimed to assess significance neutrophil lymphocyte (NLR) AIS its related complications explore their association post-stroke recovery trajectory. Arksey O’Malley methodological framework was employed published papers neutrophil–lymphocyte ratio late November 2020. Only studies English from 2000–2020 were included this review. Fifty-three reviewed. This review’s key finding that canonical inflammatory response occurs hyperacute, acute, subacute, chronic stages stroke. An excessive circulating cells (neutrophils) reduced (lymphocytes) are associated poorer outcomes interventions as well findings highlights utility systems biology-based approach care.